2DMS SpectrA

2D mass spectra contain not just the mass spectrum of the

analytes from the sample (shown by the autocorrelation line

on the figure) like a traditional mass spectrum, but also the

fragmentation pattern of every precursor ion (the fragment

ion scan), the precursor pattern of every fragment ion (the

precursor ion scan), and neutral loss and dissociation lines

that can be used to find classes of ions in the sample that

fragment in identical ways – indicative of similar structures

(protein forms with different post-translational modifications,

for example).


An example of a 2DMS plot is given below.

image37