APPLICATIONS
Lipidomics
Complex samples
Complex samples
The use of UVPD fragmentation combined with the automatic correlation of precursors with their fragments means that the technique can be used to identify specific lipids. The combination of UVPD fragmentation with total correlation enables the precise identification of identification of the head group, fatty acid chains and the location
The use of UVPD fragmentation combined with the automatic correlation of precursors with their fragments means that the technique can be used to identify specific lipids. The combination of UVPD fragmentation with total correlation enables the precise identification of identification of the head group, fatty acid chains and the location of the double bonds. Multiple lipids can be detected and analysed simultaneously, as fragments can be correlated to the precursors using the ToC-MS technique.
Complex samples
Complex samples
Complex samples
Many industries have complex samples that rely on separation techniques to enable analysis of multiple analytes. ToC-MS will increase the number of analytes detected and simultaneously improve the quality of the data by providing MS/MS data for every precursor. A key benefit of ToC-MS is that the total MS//MS data set will enable retrosp
Many industries have complex samples that rely on separation techniques to enable analysis of multiple analytes. ToC-MS will increase the number of analytes detected and simultaneously improve the quality of the data by providing MS/MS data for every precursor. A key benefit of ToC-MS is that the total MS//MS data set will enable retrospective sample analysis when new analytes of interest are identified in a project.
Proteomics/Multi-omics
Wastewater-based epidemiology
Wastewater-based epidemiology
The technique’s capacity to provide MS/MS data for all precursors in a complex sample means that it can provide game-changing improvements in the quantity and quality of data, valuable to researchers across all the different omics disciplines. The technique also provides high levels of sample reproducibility, as well as elevated sensitivity for analytes with lower abundancy.
Wastewater-based epidemiology
Wastewater-based epidemiology
Wastewater-based epidemiology
The complexity of wastewater has limited the use of data independent analytical techniques. By simultaneously providing structural and accurate mass data, ToC-MS has the ability to thoroughly profile wastewater and is able to identify where fragments are shared between multiple precursors. This allows users to rapidly detected related spe
The complexity of wastewater has limited the use of data independent analytical techniques. By simultaneously providing structural and accurate mass data, ToC-MS has the ability to thoroughly profile wastewater and is able to identify where fragments are shared between multiple precursors. This allows users to rapidly detected related species, like metabolites or illicit analogues of prescription medicines, and identify their structural differences. UVPD further enhances this ability by allowing for structural informative fragmentation of aromatic and cyclic rings, which is not possible by conventional MS/MS techniques.